Serotonin Centers franchise
A wellness center providing medical weight management, cosmetic and related services. At the end of 2025 there were 11 Serotonin Centers locations in the US, 8 franchised and 3 company-owned.
- Cost to open
- $905K–$1.82M
- Franchise fee
- $59,000
- Royalty
- 7%; $2,500 monthly minimum
- Locations, 2025
- 11+8 in 3 yrs
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Company snapshot
- SBA loans
- Not on the SBA Franchise Directory
From SEROTONIN ENTERPRISES LLC’s 2026 filing; SBA status from the SBA Franchise Directory, October 28, 2026.
How much a Serotonin Centers franchise costs
Opening Single center costs an estimated $905,284 to $1,820,879. That covers the franchise fee and everything else needed to open, through the first months of working capital.
Source: SEROTONIN ENTERPRISES LLC, 2026 filing, page 29
Serotonin Centers franchise fee
The franchise fee is $59,000. You pay it when you sign the franchise agreement.
Source: SEROTONIN ENTERPRISES LLC, 2026 filing, page 15
Royalty and ongoing fees
| Royalty | 7% of gross revenue or $2,500 monthly, whichever is greater. |
|---|
The typical franchise royalty is 6% of sales, plus 2% for marketing. See franchise fees and royalties to compare.
Source: SEROTONIN ENTERPRISES LLC, 2026 filing, page 17
Sales and earnings
Shares figures Serotonin Centers publishes sales or earnings figures for its locations. The full tables, with notes on which locations are counted, are in its filing.
Source: SEROTONIN ENTERPRISES LLC, 2026 filing, page 69
Locations opened and closed
| Year | Franchised | Company-owned | Closed |
|---|---|---|---|
| 2023 | 2 (+2) | 2 | 0 |
| 2024 | 6 (+4) | 3 | 2 |
| 2025 | 8 (+2) | 3 | 5 |
Closed or left counts terminations, non-renewals, locations bought back by the franchisor and locations that stopped operating.
See which brands grew most in the fastest-growing franchises rankings.
Source: SEROTONIN ENTERPRISES LLC, 2026 filing, page 71
How Serotonin Centers compares
Of the 21 spa franchises on this site, Serotonin Centers is the 19th cheapest to open and the 17th largest by number of locations.
| Measure | Serotonin Centers | Typical spa |
|---|---|---|
| Cost to open, low end | $905K | $573K |
| Royalty | 7% | 7% |
| Closed or left per year | 91.7% | 2.1% |
| Shares earnings figures | Yes | 18 of 21 |
Typical is the median across the 21 brands in spa franchises.
