The Medicine Shoppe franchise
A retail pharmacy dispensing prescriptions and selling health products. At the end of 2026 there were 244 The Medicine Shoppe locations in the US, all franchised.
- Cost to open
- $521K–$914K
- Franchise fee
- $0
- Royalty
- 3% or qualifying $599 monthly option
- Locations, 2026
- 244
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Company snapshot
- SBA loans
- Not on the SBA Franchise Directory
From MEDICINE SHOPPE INTERNATIONAL, INC’s 2026 filing; SBA status from the SBA Franchise Directory, October 28, 2026.
How much a The Medicine Shoppe franchise costs
Opening New pharmacy costs an estimated $521,150 to $913,653. That covers the franchise fee and everything else needed to open, through the first months of working capital.
Source: MEDICINE SHOPPE INTERNATIONAL, INC, 2026 filing, page 23
The Medicine Shoppe franchise fee
The franchise fee is $0. You pay it when you sign the franchise agreement.
Source: MEDICINE SHOPPE INTERNATIONAL, INC, 2026 filing, page 16
Royalty and ongoing fees
| Royalty | 3% of gross sales; an optional purchasing commitment can replace this with a $599 monthly license fee. |
|---|
The typical franchise royalty is 6% of sales, plus 2% for marketing. See franchise fees and royalties to compare.
Source: MEDICINE SHOPPE INTERNATIONAL, INC, 2026 filing, page 16
Sales and earnings
No figures The Medicine Shoppe does not share sales or profit figures for its locations. Talking to current and former franchise owners is the usual way to learn what a location earns.
Source: MEDICINE SHOPPE INTERNATIONAL, INC, 2026 filing, page 49
Locations opened and closed
| Year | Franchised | Company-owned |
|---|---|---|
| 2024 | 292 (−5) | 0 |
| 2025 | 271 (−21) | 0 |
| 2026 | 244 (−27) | 0 |
Closed or left counts terminations, non-renewals, locations bought back by the franchisor and locations that stopped operating.
See which brands grew most in the fastest-growing franchises rankings.
Source: MEDICINE SHOPPE INTERNATIONAL, INC, 2026 filing, page 50
How The Medicine Shoppe compares
Of the 65 retail franchises on this site, The Medicine Shoppe is the 60th cheapest to open and the 22nd largest by number of locations.
| Measure | The Medicine Shoppe | Typical retail |
|---|---|---|
| Cost to open, low end | $521K | $224K |
| Change in franchised locations, 0 yrs | −17.8% | +4.8% |
| Shares earnings figures | No | 56 of 65 |
Typical is the median across the 65 brands in retail franchises.
